statistical methodology for high-dimensional data sets, with applications in a diverse set of areas spanning the social, physical, and biomedical sciences. Three areas of methodological focus include (1) large-scale multiple testing, anomaly-detection and screening problems, where the rate of false discoveries must be controlled in order to yield viable inferences; (2) inference in sparse models; and (3) the application of data-augmentation theory and algorithms to improve the efficiency of Bayesian inference in large-scale models for discrete data sets.-faculty profile