Sam Kiehl, a 42-year-old Vietnam vet and political analyst, signs up for a double-blind placebo-controlled study at an esteemed research center in Oregon after being diagnosed with herpes. The curiously named pharmaceutical company, Physicians for Ethical Research (PER), is optimistic over its promising drug, Zomalovir. Sam soon strikes up a romance with his massage therapist, Jessica Foster, but after PER goes bankrupt and cancels the Zomalovir study, the distraught subjects (including Sam) resort to desperate measures to continue receiving treatment.

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