Documents the first conference on the topic, called in response to opportunities opened by the molecular characterization of the first mammalian mono (ADP-ribosyl) transferase enzyme from rabbit skeletal muscles, and the subsequent realization that one had already been to hand in a well-studied surface membrane protein of T cells, RT6. After introductions to the emerging gene families, the history of ADT- Ribose, and ADP-Ribosylation cycles, the 59 papers cover lessons from procaryotes, molecular approaches to studies in eucaryotes, the enzyme in the immune system and other animal tissues, the physiology of membrane proteins anchored by GPI, NAD+glycohydrolases and ADP- ribosylcyclases, and contemplation of the evolution of the enzyme in the context of the immune system. Appended is a proposal for a unified nomenclature for the relevant vertebrate gene family.

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