Proceedings of the Eighth Henry Goldberg Workshop in [title], held December 1992, in Bethesda, Maryland. Thirty-eight contributions address electromechanical activation, mechanics and microcirculation, microcirculation and metabolic transport, remodeling of muscle and vessels, and cardiac function and circulation. Integrated analysis chapters discuss the integrated functioning of heart and lungs, carotid-cardiac interaction, macroscopic three-diminsional motion patterns of the left ventricle, and cardiovascular flow velocity measurements.