Abstract: A reference text for researchers, students, biochemists, and clinicians interested in the area of lipoprotein metabolism presents 14 authoritative reviews prepared by experts in their respective fields, directed at the current state of knowledge on high-density lipoprotein (HDL) metabolism and how it relates to cholesterol transport. Topics include: the structure and metabolism of HDL; proteolytic enzymes in the synthesis and metabolism of plasma HDL; the effect of chylomicron lipolysis on HDL; human apolipoprotein gene expression; cholesterol flux between HDL and cells; cholesterol solubilization by HDL; the role of HDL receptors in macrophage cholesterol metabolism; binding sites for HDL and HDL catabolism; isoforms of plasma apolipoprotein A-1 in animals; the clinical significance of HDL; genetic, clinical, and biochemical features of an apolipoprotein A-1 variant; HDL in hypertriglyceridemia; familial hypoalphalipo-proteinemia; and the dietary and drug effects on HDL metabolism. Key research areas also are identified, including HDL receptors and enzymatic processing of plasma apoproteins.