Reviewing over a century of aspirin research and use, this book provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of aspirin, it reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs.