A devastating bioweapon is released in every major city, sending the population into a murderous rage. Nuclear war rages across the globe. Retired Special Forces soldier John Chase is 1,500 miles from home when the world descends into chaos. He is determined to return to his wife, but before he can begin his journey across the shattered remains of America, he rescues a young woman from an enraged group of infected. Forced to rely on each other simply to survive, they begin a journey fraught with constant danger and the unimaginable horrors of a dying world gone mad.