Vaccine discovery is one of the most exciting and fast-moving areas of applied science. Since Edward Jenner’s work in the 18th century, vaccines have transformed health across the globe. Bringing together clinical, experimental, and computational disciplines vaccinology addresses the most pressing needs of 21st century health-care: the great infectious diseases threatening the developing world, such as HIV, Malaria, and TB; and chronic diseases, such as dementia, threatening the developed world. This volume seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.