This book examines every aspect of vaccination - from development to use in reducing disease. Completely revised and updated, it provides authoritative information on vaccine production, available preparations, efficacy, and safety-recommendations for vaccine use, with rationales-data on the impact of vaccination programs on morbidity and mortality-and more. The book provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health issues. It discusses the proper use of immune globulins and antitoxins; examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies; and illustrates concepts and objective data with over 605 tables and figures.