This volume in the Handbook of Clinical Neurology series includes chapters dealing with general aspects of headache (socioeconomic in particular), the contribution made by the biological sciences to furthering understanding of the pathophysiology of headache, and the managemnt of headache and related problems. The main body of the book is devoted to primary and secondary headaches. The book ends with some chapters intended to clarify a series of controversial issues: pathogenetic (chronobiological, endocrinological and neuroimaging correlates), nosographic (ie migraine, vertigo and headache in children) and treatment-related (new advances).