The first volume of the 4th Edition of the World Health Organization series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors. The book, prepared by 73 authors from 19 countries, contains more than 400 colour photographs, numerous X-rays, computed tomography (CT), magnetic resonance (MR) images, charts, and more than 2,500 references.