Uses intriguing case studies, frequent questions, and thorough discussions of fundamental principles to frame physiology as a subject of real importance to clinical practice. Thoroughly up-to-date with the latest research on basic principles, clinical practice, and discoveries in molecular biology, this text serves as an ideal springboard for medical school courses in physiology. Key-concept summaries spotlight important points. Numerous questions support step-by-step mastery and critical thought. "Clinical pearls" illuminate diagnostic and treatment applications of physiologic concepts. Over 400 illustrations clarify key concepts. Frontiers sections point where research may be headed. Tables and charts present detailed data accessibly. Challenging real-world cases, many based on actual errors. made on the wards, test your grasp of concepts Case-solved sections fully explain chapter-opening studies, with citations to the text.