These proceedings of an international symposium held in Buffalo, New York, October 1993, include chapters from platform presentations, poster sessions, and from invited special lectures in the areas of basic science, clinical applications, and efficacy of treatment. The volume is divided into sections devoted to pathophysiology and analysis, organ specific disorders, systemic involvement, and therapeutic intervention. Among the titles are lipid peroxides and related radicals in clinical medicine; free radicals and the pathogenesis of neuronal death--cooperative role of excitatory amino acids; and autoimmune and inflammatory diseases.