Against a backdrop of contemporary social and sexual concerns, and potent fears surrounding the moral and physical 'degeneration' of late nineteenth and early twentieth-century society, this book explores a critical period in the developing relationship between syphilis and insanity. General paralysis of the insane (GPI), the most commonly diagnosed of the neurosyphilitic disorders, has been devastating both in terms of its severity and incidence. Using the rich laboratory and asylum records of lowland Scotland as a case study, Gayle Davis examines the evolution of GPI as a disease category from a variety of perspectives: social, medical, and pathological. Through exploring case notes and the impact of new diagnostic techniques and therapies, such as the Wassermann Test and Malarial Therapy, the reader gains a unique insight into both patients and practitioners. Significant insights are gained into the socio-sexual background and medical experience of patients, as well as the clinical ideas and judgmental behaviour of the practitioners confronting this disease.