Dr. Thea Sperelakis, diagnosed as a teen with Asperger's syndrome, has always been an outsider. She has a brilliant medical mind, and a remarkable recall of details, but her difficulty in dealing with hidden agendas and interpersonal conflicts have led her to leave the complex, money-driven dynamics of the hospital, and to embrace working with the poor, embattled patients of Doctors Without Borders. Her father, Petros, is one of the most celebrated internal medicine specialists in the world, and the founder of the cutting-edge Sperelakis Center for Diagnostic Medicine at Boston's sprawling, powerful Beaumont Clinic. Thea's rewarding life in Africa is turned upside-down when Petros is severely injured by a hit-and-run driver. He is in the Beaumont ICU, in a deep coma. No one thinks he will survive. Thea must return home. Two of Petros' other children, both physicians, battle Thea and her eccentric brother, Dimitri, by demanding that treatment for their father be withheld. As Thea uncovers the facts surrounding the disaster, it seems more and more to be no accident. Petros, himself, is the only witness. Who would want him dead? The answers are trapped in his brain. In The Second Opinion, Michael Palmer has created a cat-and-mouse game where one woman must confront a conspiracy of doctors to uncover an evil practice that touches every single person who ever has a medical test.