Patent Protection for Second Medical Uses' explains the key jurisdictional differences and challenges in protecting and enforcing second medical use (SMU) claims. When a party proposes an SMU for a known substance or compound, special issues of patentability arise as they form an important component of the potential second-line patent protection. Jurisdictions around the world vary significantly in their treatment of such claims. This compendium of contributions from nineteen jurisdictions worldwide is the result of the need for a broader and more detailed exposition in SMU in order to allow comparison between jurisdictions.