This one-page minicomic is written and drawn by Roberta Gregory, who also writes the comic "Naughty Bits." She is known for her raunchy, sexual humor. Female Problems's details the "unspeakable horrors" men will have to face in the following pages, such as an explanation of female reproductive anatomy and a demonstration of diaphragm insertion. Also included is a comic about how communication between men and women remains complicated even when both are politically aware, one about two cats who wonder why they aren't attracted to tomcats anymore after a mysterious trip to the vet, and a list of recommendations of other comics and comics vendors.