Completely rewritten and updated, this new edition is almost twice the size of its predecessor. It presents practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes three chapters on neuroimaging, molecular diagnostics, and transgenic models; two chapters on tauopathies under new authorship and a chapter under new authorship on synucleinopathies, including multiple system atrophy.