This comprehensive review of the orbitofrontal cortex starts with a review of the structure of the ventral frontal lobes in human and nonhuman primates and the current state of knowledge regarding the region's neurocircuitry. This is followed by a series of chapters addressing the precise functions of the orbitofrontal cortex, with coverage spanning animal and human research. The book continues with chapters detailing methodological issues in neuroimaging and neuropsychological assessment of the region, and concludes with reviews of the area's contribution to psychiatric and neurological conditions.