This book constitutes the refereed proceedings of the 10th Asian Symposium on Programming Languages and Systems, APLAS 2012, held in Kyoto, Japan, in December 2012. The 24 revised full papers presented together with the abstracts of 3 invited talks were carefully reviewed and selected from 58 submissions. The papers are organized in topical sections on concurreny, security, static analysis, language design, dynamic analysis, complexity and semantics, and program logics and verification.