The Progress in Medicinal Chemistry series is a respected and instructive source of information on the subject. It has a long established reputation for excellent coverage of almost every facet of medicinal chemistry. This volume includes information on the discovery and development of Atorvastatin; the discovery of CEP-1347/KT-7515, an JNK/SAPK pathway for the treatment of neurodegenerative diseases such; and the discovery of second generation Quinazolinone non-nucleoside reverse transcriptase inhibitors of HIV-1; and molecular modeling of Opioid receptor-Ligand complexes.