The race is on to claim the area between the Ohio River and Tennessee. What's left of the resistance is hiding out in the tangle of central Kentucky hills- leaving the powerful, well-organized Kurian vampires the opportunity to fill the void. Major David Valentine knows there's only one way for them to find help before the Kurians settle in: a desperate dash by hijacked rail, followed by a harrowing river journey. Valentine unites friends old and new in the effort- but the Kurian Order won't easily yield the blood-soaked Kentucky soil.