The Editors have taken the occasion of Professor John A. Buzacott's retirement as a motivating event to develop this volume. The objectives of Stochastic Modeling And Optimization Of Manufacturing Systems And Supply Chains is to both honor John Buzacott's achievements and to publish a set of well-written chapters on highly timely topics in the field of manufacturing and supply chain management. The book is organized into two parts. The first part focuses on aspects of manufacturing systems modeling. The second part focuses on production-inventory systems and supply chains. The book examines cutting-edge topics that have been invited and organized by the Editors from leading researchers in the field. Each chapter presentation has been carefully reviewed and crafted by the Editors and contributing authors. The volume is a fitting recognition of John Buzacott's lifetime contributions to this field.