Set in 1940s Appalachia, The Secret Sense of Wildflower tells the story of Louisa May "Wildflower" McAllister whose life has been shaped around the recent death of her beloved father in a sawmill accident. While her mother hardens in her grief, Wildflower and her three sisters must cope with their loss themselves, as well as with the demands of daily survival. Despite these hardships, Wildflower has a resilience that is forged with humor, a love of the land, and an endless supply of questions to God. When Johnny Monroe, the town's teenage ne'er-do-well, sets his sights on Wildflower, she must draw on the strength of her relations, both living and dead, to deal with his threat.