This supplementary text for applied mathematics courses where Mathematica is used in a laboratory setting, is intended to be compatible with a broad range of engineering mathematics texts, as well as smaller, more specialized texts in differential equations and complex variables. It covers topics found in courses on ordinary and partial differential equations, vector analysis, and applied complex analysis. Students are guided through a series of laboratory exercises that present cogent applications of the mathematics and demonstrate the use of Mathematica as a computational tool to do the mathematics. Relevant applications along with discussions of the results obtained combine to stimulate innovative thinking from the students about additional concepts and applications.