Deagan and Cruxent present detailed technical documentation of their ten-year archaeological excavation of La Isabela, America's first colony. The artifacts and material remains of the town offer rich material for comparative research into Euro-American cultural and material development during the transition from the medieval era to the Renaissance. The period when La Isabela was in existence witnessed great innovation and change in many areas of technology. The archaeological evidence of La Isabela can be precisely dated, helping to chart the sequence of this change and revealing much that is new about late mediaeval technology.